Although hypoxia is also known to modulate inflammatory gene expression, little is known about how hypoxia or P 2 X receptor activation alone affects inflammatory molecule production in brainstem microglia, nor how hypoxia and P 2 X receptor signaling interact when they occur together. Extracellular nucleotides are potent modulators of microglial inflammatory gene expression via P 2 X purinergic receptor activation. Hypoxia and increased extracellular nucleotides are frequently coincident in the brainstem. Smith, Stephanie MC Mitchell, Gordon S Friedle, Scott A Sibigtroth, Christine M Vinit, Stéphane Watters, Jyoti J Hypoxia attenuates purinergic P 2 X receptor-induced inflammatory gene expression in brainstem microglia
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